大健康产业 - The Grand Health Industry
- 人工智能模型配置与合成生物技术布局， 企业转型升级的规划，提升竞争实力的发展策略。
- 经济和商业发展，必须是产业政策与市场机制的协调，传统文化精神与现代科学方法的结合。
System engineering design scheme for the great health industry
- AI model configuration and synthetic biology technology layout, enterprise transformation and upgrading planning, development strategies to enhance competitiveness.
- Economic and commercial development must be the coordination of industrial policy and market mechanism, the combination of traditional cultural spirit and modern scientific methods.
医学发展概览 - 4轴心时代与4世界理论
人类文明一万年，从农业起源到城市发展，形成城市群的地缘文化学模式。
1-古典文明 - 文化模式与a-教育精神奠基，传统节日起源。
2-中古代与丝绸之路 - 博物学与b-理性知识的发展，娱乐工具发明，手工业技术与工艺的工程设计模式。
天象观测，农业育种与医疗药物开发 - 唐代医学教育形成，11世纪意大利建立医学院。
3-地理探险时代 - 机器自然观和科学范式建立，揭示c-自然现象内在规律，数学工具和仪器技术的发明，工程模型与标准化工业设计。
1865年法国C.贝尔纳论述实验医学，1885年法国L.巴斯德哪年建立疫苗接种，上海圣约翰大学在1906年开展现代医学教育。
1926年美国哈佛大学WB. Cannon提出内环境的稳态概念，1946年威尔金斯和兰德尔开展DNA结构研究，1961年法国莫诺和雅各布发表操纵子模型，1977年美国G.Engel提出生物-心理-社会医学模式。
4-人类世 - d-人工机器与生物设计，1948年冯·诺依曼在加州理工大学做了自动机理论的讲演，1984年安德森和盖尔曼等建立圣塔菲研究所 - C.兰顿在1987年提出人工生命的概念。
1992年中国Bj.Zeng提出系统医学与药物学的概念和模型 - 并在1994年论述了系统遗传学和系统生物工程的概念和方法，1996-1999年组织第一届国际转基因动物学术研讨会和筹建系统生物科学与工程联盟。
1910年S.Leduc物理化学与形态学的合成生物学,1968年D.Mesarovic数学方法的理论与系统生物学，转换到生物系统理论与人工生物系统设计，及其方法 - 计算与生物信息学和实验与生物技术。
2003年哈佛大学成立系统生物学系，MIT开展iGEM竞赛，2006年伯克利大学J.Keasling合成青蒿素，2007年ETH大学建立生物系统科学与工程系。
2012年欧盟在都柏林举办国际系统医学大会，2015年在斯德哥尔摩举办2015年夏季学院课程。
Overview of Medical Development
- The 4-axis era and the 4-world theoryTen thousand years of human civilization, from the origins of agriculture to urban development, forming the geoculturological pattern of cities groups.
1-Classical civilization - Established the foundation for cultural patterns and a-Educational spirit, and the origin of traditional festivals.
2-Medieval Era and the Silk Road - b-Rational knowledge development and discoveries in natural history, invention of entertainment tools, engineering design patterns of handicraft technology and craftsmanship.
Astronomical observation, agricultural breeding and medical development - Formation of medical education in the Tang Dynasty, the first medical school was established in Italy in the 11th century.
3-Age of geographical exploration - Establishment of the mechanical view of nature and scientific paradigm, reveal the inherent laws of c-Natural phenomena, invention of mathematical tools and instrument technology, engineering models and standardized industrial design.
1865, French C. Bernard discussed experimental medicine; 1885, French L. Pasteur established vaccination; St. John's University in Shanghai began modern medical education in 1906.
In 1926 Harvard University, WB. Cannon proposed the concept of internal homeostasis; In 1946, M. Wilkins and J. Randall conducted research on the structure of DNA; In 1961, J.L. Monod and F. Jacob published the operon model; 1977, American G. Engel proposed the biopsychosocial model of medicine.
4-Anthropocene - d-Artificial machine and biological design, In 1948, von Neumann gave a lecture on automata theory at the California Institute of Technology; in 1984, FW. Anderson, M. Gell-Mann, and others established the Santa Fe Institute - C. Langton proposed the concept of artificial life in 1987.
1992, Chinese Bj. Zeng proposed the concepts and models of systems medicine and pharmacology - and in 1994 discussed the concepts and methods of systems genetics and systems bioengineering; from 1996 to 1999, organized the first international conference on transgenic animals and prepared for the establishment of the Associaties for Bio-Systems Science and Engineering.
1910 S. Leduc's physical chemistry and morphological synthetic biology, 1968 D. Mesarovic's mathematics and theoretical systems biology, transitioning to biological systems theory and artificial biological systems design, and its methods - computational and bioinformatics, experimental and biotechnology.
In 2003, Harvard University established the department of systems biology, MIT launched the iGEM competition, in 2006 J. Keling at UC Berkeley synthesized artemisinin, and in 2007 ETH Zurich established the department of Bio-Systems Science and Engineering.
In 2012, the EU hosted the International Congress of Systems Medicine in Dublin, and in 2015, it hosted the 2015 Summer School in Stockholm.
生物制造工业 - 应用合成生物学的产业转化
需要分辨 - 合成化学与生物合成，化学合成与合成生物，一般是形成三个阶段：
上游 - 基本上是计算技术和生物技术等；中游 - 工程细胞的设计与合成 - 包括，细胞和非细胞，比如，分子机器与DNA计算机等；下游 - 发酵工艺和代谢产物提纯技术等。
其中，包括，合成生物技术的平台类型，大规模产业化的产品类型。
Biomanufacturing industry - Industrial translation of applied synthetic biology
Need to distinguish - synthetic chemistry and biosynthesis, chemical synthesis and synthetic biology, generally forming three stages:
Upstream - basically computing technology, biotechnology, etc.; Midstream - design and synthesis of engineered cells - including cellular and non-cellular, such as molecular machines and DNA computers; Downstream - fermentation processes and metabolite purification technologies, etc.
Among them, including the technology platform types of synthetic biology, and the product types of large-scale industrialization.
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The World of Systems Medicine
